The Journal of Phytopharmacology 2022; 11(4):243-246 ; DOI:10.31254/phyto.2022.11403
Amelioration of experimental nephrotoxicity due to 5-Flourouracil by Resveratrol in comparison to Vitamin-E
Bommineni Harish1 , Pabbathi Shivakumar2 , Bharani Kala Kumar2 , Boinapally Ramya3 , Nisaath Begum1 , Matukumalli Usha Rani4 , Banothu Anil Kumar2
1. P.G Scholar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, P.V. Narasimha Rao Telangana Veterinary University, Rajendranagar, Hyderabad, 500030, Telangana, India
2. Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, P.V. Narasimha Rao Telangana Veterinary University, Rajendranagar, Hyderabad, 500030, Telangana, India
3. Assistant Professor, Veterinary Clinical Complex, College of Veterinary Science, P.V. Narasimha Rao Telangana Veterinary University, Rajendranagar, Hyderabad, 500030, Telangana, India
4. Professor and Head, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, P.V. Narasimha Rao Telangana Veterinary University, Rajendranagar, Hyderabad, 500030, Telangana, India
*Author to whom correspondence should be addressed.
Received: 16th June, 2022 / Accepted: 2nd August, 2022
The therapeutic efficacy of Resveratrol (RSV) and Vitamin E were studied against 5-Flourouracil (5-FU) induced nephrotoxicity. 36 male Wistar rats were selected randomly weighing between 150-180 g and are made into 6 groups, each group containing 6 rats. Group 1 was maintained as sham. 5-Flourouracil was administered to groups 2, 5 and 6 intraperitoneally (20 mg/kg body weight) on day 1, 3 and 7. Group 2 was kept as positive control (administered 5-FU intraperitoneally). Groups 3, 5 and 4, 6 were administered vitamin E and resveratrol per orally for 14 days @ 200 mg/kg bwt. At the end of the experiment the blood was withdrawn and serum analyzed for renal biomarkers. For histopathological studies, samples of kidney tissue collected by inducing euthanasia in rats. The sero-biochemical analysis revealed a significant increase in BUN and creatinine values of the rats in group 2. The antioxidant activity was analyzed and the rats in group 2 revealed a significant rise in the values of protein carbonyl, TBARS and significant decrease in GSH. Group 2 also showed an increase in TNF-? and decrease in interleukin-10 concentration. Sections of kidney tissue collected from group 2 showed marked dilation and elongation of tubules, moderate infiltration with inflammatory cells degeneration of bowman’s capsule and tubular congestion. Comparatively, groups undergone treatment showed amelioration in the parameters. Thus, resveratrol and vitamin-E exert protective actions against 5-flourouracil (5-FU) induced nephrotoxicity.
5-Flourouracil, Resveratrol, Vitamin-E, Nephrotoxicity
HOW TO CITE THIS ARTICLE
Harish B, Shivakumar P, Kumar BK, Ramya B, Begum N, Rani MU, Kumar BA. Amelioration of experimental nephrotoxicity due to 5-Flourouracil by Resveratrol in comparison to Vitamin-E. J Phytopharmacol 2022; 11(4):243-246. doi: 10.31254/phyto.2022.11403
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